Abstract
Modelling studies have been carried out on the phosphodiesterase (PDE) substrates, adenosine- and guanosine-3'5'-cyclic monophosphates, and on a number of non-specific and type III-specific phosphodiesterase inhibitors. These studies have assisted the understanding of PDE substrate differentiation and the design of potent, selective PDE type III inhibitors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Computer Graphics
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Computer Simulation
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Cyclic AMP
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Cyclic GMP
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Drug Design*
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Molecular Conformation
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Phosphodiesterase Inhibitors*
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Phosphoric Diester Hydrolases / metabolism*
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Structure-Activity Relationship
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Substrate Specificity
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Thermodynamics
Substances
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Phosphodiesterase Inhibitors
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Cyclic AMP
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Phosphoric Diester Hydrolases
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Cyclic GMP