ModelFinder: fast model selection for accurate phylogenetic estimates

Nat Methods. 2017 Jun;14(6):587-589. doi: 10.1038/nmeth.4285. Epub 2017 May 8.


Model-based molecular phylogenetics plays an important role in comparisons of genomic data, and model selection is a key step in all such analyses. We present ModelFinder, a fast model-selection method that greatly improves the accuracy of phylogenetic estimates by incorporating a model of rate heterogeneity across sites not previously considered in this context and by allowing concurrent searches of model space and tree space.

Publication types

  • Evaluation Study

MeSH terms

  • Algorithms*
  • Animals
  • Chromosome Mapping / standards*
  • Computer Simulation
  • Evolution, Molecular
  • High-Throughput Nucleotide Sequencing / methods*
  • Humans
  • Models, Genetic*
  • Models, Statistical
  • Phylogeny*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sequence Analysis, DNA