Development of a bioactive glass-polymer composite for wound healing applications

D Moura; M T Souza; L Liverani; G Rella; G M Luz; J F Mano; A R Boccaccini

doi:10.1016/j.msec.2017.03.037

Development of a bioactive glass-polymer composite for wound healing applications

Mater Sci Eng C Mater Biol Appl. 2017 Jul 1:76:224-232. doi: 10.1016/j.msec.2017.03.037. Epub 2017 Mar 6.

Authors

D Moura¹, M T Souza², L Liverani³, G Rella³, G M Luz⁴, J F Mano⁵, A R Boccaccini⁶

Affiliations

¹ 3B's Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark-Parque de Ciência e Tecnologia, 4805-017 Barco, Taipas, Guimarães, Portugal; ICVS/3B's, Associate PT Government Laboratory, Braga, Guimarães, Portugal; Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerst.6, 91058 Erlangen, Germany.
² Vitreous Material Laboratory - LaMaV, Department of Material Science and Engineering - DEMa, Federal University of Sao Carlos - UFSCar, São Carlos, São Paulo, Brazil; Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerst.6, 91058 Erlangen, Germany.
³ Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerst.6, 91058 Erlangen, Germany.
⁴ 3B's Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark-Parque de Ciência e Tecnologia, 4805-017 Barco, Taipas, Guimarães, Portugal; ICVS/3B's, Associate PT Government Laboratory, Braga, Guimarães, Portugal.
⁵ 3B's Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark-Parque de Ciência e Tecnologia, 4805-017 Barco, Taipas, Guimarães, Portugal; ICVS/3B's, Associate PT Government Laboratory, Braga, Guimarães, Portugal; Department of Chemistry, CICECO- Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: jmano@ua.pt.
⁶ Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerst.6, 91058 Erlangen, Germany. Electronic address: aldo.boccaccini@ww.uni-erlangen.de.

PMID: 28482521
DOI: 10.1016/j.msec.2017.03.037

Abstract

This study reports the production and characterization of a composite material for wound healing applications. A bioactive glass obtained by sol-gel process and doped with two different metal ions was investigated. Silver (Ag) and cobalt (Co) were chosen due to their antibacterial and angiogenic properties, respectively, very beneficial in the wound healing process. Poly(ε-caprolactone) (PCL) fibers were produced by electrospinning (ES) from a polymeric solution using acetone as a solvent. After optimization of the ES parameters, two main suspensions were prepared, namely: PCL containing bioactive glass nanoparticles (BG-NP) and PCL with Ag₂O and CoO doped BG-NP (DP BG-NP), which were processed with different concentrations of BG-NP (0.25%, 0.5% and 0.75wt%). The composite membranes were characterized in terms of morphology, fiber diameter, weight loss, mineralization potential and mechanical performance.

Keywords: Bioactive glass; Electrospinning; Mineralization; PCL; Wound healing.

MeSH terms

Biocompatible Materials
Glass
Polyesters
Polymers / chemistry*
Tissue Engineering
Wound Healing

Substances

Biocompatible Materials
Polyesters
Polymers