Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity

Trends Biochem Sci. 2017 Jul;42(7):531-542. doi: 10.1016/j.tibs.2017.04.003. Epub 2017 May 5.


Polycomb repressive complex 2 (PRC2) and its histone H3 lysine-27 methylation activity are crucial for multicellular development by virtue of their role in maintaining transcriptional repression patterns. The recruitment and enzymatic activity of PRC2 are controlled by a series of intricate mechanisms whose molecular details have been emerging at a rapid pace. Recent studies have uncovered intriguing modes of PRC2 regulation by facultative PRC2 subunits, PRC1, and specific features of the chromatin environment. Together, these findings have produced a rich and fast-evolving picture of the biochemical signals that govern PRC2 function, with many exciting questions still remaining.

Keywords: H3K27me3; PRC1; PRC2; PRC2 facultative subunits; PRC2 regulation; transcriptional repression.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Polycomb Repressive Complex 2 / metabolism*


  • Polycomb Repressive Complex 2