Polycomb repressive complexes in hematological malignancies

Blood. 2017 Jul 6;130(1):23-29. doi: 10.1182/blood-2017-02-739490. Epub 2017 May 8.


The deregulation of polycomb repressive complexes (PRCs) has been reported in a number of hematological malignancies. These complexes exert oncogenic or tumor-suppressive functions depending on tumor type. These findings have revolutionized our understanding of the pathophysiology of hematological malignancies and the impact of deregulated epigenomes in tumor development and progression. The therapeutic targeting of PRCs is currently attracting increasing attention and being extensively examined in clinical studies, leading to new therapeutic strategies that may improve the outcomes of patients with hematological malignancies.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Epigenesis, Genetic*
  • Gene Expression Regulation, Neoplastic*
  • Hematologic Neoplasms* / genetics
  • Hematologic Neoplasms* / metabolism
  • Hematologic Neoplasms* / pathology
  • Humans
  • Neoplasm Proteins* / genetics
  • Neoplasm Proteins* / metabolism
  • Polycomb-Group Proteins* / genetics
  • Polycomb-Group Proteins* / metabolism


  • Neoplasm Proteins
  • Polycomb-Group Proteins