Dalmatian: spotting the difference in cohesin protectors

EMBO J. 2017 Jun 1;36(11):1468-1470. doi: 10.15252/embj.201797090. Epub 2017 May 8.

Abstract

The cohesin complex prevents separation of chromosomes following their duplication until the appropriate time during cell division. In vertebrates, establishment and maintenance of cohesin-dependent linkages depend on two distinct proteins, sororin and shugoshin. New findings published in The EMBO Journal show that in Drosophila, the function of both of these cohesin regulators is carried out by a single hybrid protein, Dalmatian.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics
  • Chromatids*
  • Chromosomal Proteins, Non-Histone / genetics
  • Nuclear Proteins / genetics*

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • Nuclear Proteins