LASIK for the Correction of High Hyperopic Astigmatism With Epithelial Thickness Monitoring

J Refract Surg. 2017 May 1;33(5):314-321. doi: 10.3928/1081597X-20170111-04.


Purpose: To evaluate outcomes of high hyperopic LASIK using the MEL 80 excimer laser (Carl Zeiss Meditec, Jena, Germany).

Methods: Retrospective analysis of 830 consecutive high hyperopic LASIK procedures using the MEL 80 excimer laser and either the VisuMax femtosecond laser (Carl Zeiss Meditec) or zero compression Hansatome microkeratome (Bausch & Lomb, Rochester, NY). Inclusion criteria were attempted hyperopic correction of +4.00 diopters [D] or higher in one axis and corrected distance visual acuity (CDVA) of 20/20 or better. Patients were observed for a minimum of 1 year. Epithelial thickness monitoring by Artemis very high-frequency (VHF) digital ultrasound (ArcScan Inc., Morrison, CO) was used to evaluate potential for further steepening as a re-treatment.

Results: One-year data were available for 785 eyes. Mean attempted spherical equivalent refraction (SEQ) was +4.52 ± 0.84 D (range: +2.00 to +6.96 D) for the primary treatment and mean cylinder was 1.05 ± 0.86 D (range: 0.00 to 5.25 D). Mean age was 50 ± 12 years (range: 18 to 70 years) and 61% were women. Postoperative SEQ was ±0.50 D in 50% and ±1.00 D in 77% of eyes after primary treatment. After re-treatment, 67% of eyes were within ±0.50 D and 89% were within ±1.00 D. Uncorrected distance visual acuity was 20/20 or better in 76% of eyes after final treatment. One line of CDVA was lost in 25% of eyes and two lines were lost in 0.4%. There was a clinically insignificant but statistically significant decrease (P < .05) in contrast sensitivity (CSV-1000) by less than 1 log unit at 3 and 6 cycles per degree (cpd) and by 1 log unit at 12 and 18 cpd. Diurnal fluctuation in refraction was identified in 2 eyes, proven by VHF digital ultrasound to be due to diurnal epithelial remodeling overnight and unrelated to maximum postoperative keratometry induced.

Conclusions: LASIK for hyperopia by cumulative treatment of up to +8.33 D with the MEL 80 excimer laser was found to satisfy accepted criteria for safety, efficacy, and stability when applying specialized protocols, including epithelial monitoring. [J Refract Surg. 2017;33(5):314-321.].

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Astigmatism / complications
  • Astigmatism / diagnosis
  • Astigmatism / surgery*
  • Corneal Topography / methods*
  • Epithelium, Corneal / pathology*
  • Eye Diseases, Hereditary / complications
  • Eye Diseases, Hereditary / diagnosis
  • Eye Diseases, Hereditary / surgery*
  • Female
  • Follow-Up Studies
  • Humans
  • Hyperopia / complications
  • Hyperopia / diagnosis
  • Hyperopia / surgery*
  • Keratomileusis, Laser In Situ / methods*
  • Lasers, Excimer / therapeutic use*
  • Male
  • Middle Aged
  • Monitoring, Physiologic / methods*
  • Refraction, Ocular
  • Reoperation
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Young Adult

Supplementary concepts

  • Hyperopia, High