Intrinsically Disordered Proteins Adaptively Reorganize Cellular Matter During Stress

Trends Biochem Sci. 2017 Jun;42(6):410-412. doi: 10.1016/j.tibs.2017.04.007. Epub 2017 May 6.


Intrinsically disordered proteins (IDPs) can protect cells from diverse stresses by forming higher order assemblies such as reversible aggregates or granules. Recently, Boothby et al. show that IDPs protect tardigrades against desiccation by forming a glass-like amorphous matrix, highlighting that material properties of disordered proteins can confer adaptation during stress.

Publication types

  • Comment

MeSH terms

  • Intrinsically Disordered Proteins / metabolism*
  • Stress, Physiological*


  • Intrinsically Disordered Proteins