Highly potent and selective ligands for a new class H3 of histamine receptor

Invest Radiol. 1988 Sep:23 Suppl 1:S130-2. doi: 10.1097/00004424-198809001-00017.


The third histamine receptor was first indentified on brain neurons and seems to be present in other cells such as lung mast cells. Hence the novel and potent H3-receptor agonist (R) alpha-methylhistamine might find therapeutic applications in allergic diseases.

MeSH terms

  • Animals
  • Methylhistamines*
  • Piperidines*
  • Radioligand Assay
  • Rats
  • Receptors, Histamine / drug effects
  • Receptors, Histamine / isolation & purification*
  • Receptors, Histamine H3


  • Methylhistamines
  • Piperidines
  • Receptors, Histamine
  • Receptors, Histamine H3
  • thioperamide