Molecular remodeling of the renin-angiotensin system after kidney transplantation

J Renin Angiotensin Aldosterone Syst. Apr-Jun 2017;18(2):1470320317705232. doi: 10.1177/1470320317705232.

Abstract

Objective: We aimed at assessing the molecular adaptation of the renin-angiotensin system (RAS) after successful kidney transplantation (KTX).

Materials and methods: In this prospective, exploratory study we analyzed 12 hemodialysis (HD) patients, who received a KTX and had excellent graft function six to 12 months thereafter. The concentrations of plasma Angiotensin (Ang) peptides (Ang I, Ang II, Ang-(1-7), Ang-(1-5), Ang-(2-8), Ang-(3-8)) were simultaneously quantified with a novel mass spectrometry-based method. Further, renin and aldosterone concentrations were determined by standard immunoassays.

Results: Ang values showed a strong inter-individual variability among HD patients. Yet, despite a continued broad dispersion of Ang values after KTX, a substantial improvement of the renin/Ang II correlation was observed in patients without RAS blockade or on angiotensin receptor blocker (HD: renin/Ang II R2 = 0.660, KTX: renin/Ang II R2 = 0.918). Ang-(1-7) representing the alternative RAS axis was only marginally detectable both on HD and after KTX.

Conclusions: Following KTX, renin-dependent Ang II formation adapts in non-ACE inhibitor-treated patients. Thus, a largely normal RAS regulation is reconstituted after successful KTX. However, individual Ang concentration variations and a lack of potentially beneficial alternative peptides after KTX call for individualized treatment. The long-term post-transplant RAS regulation remains to be determined.

Keywords: Renin-angiotensin system; angiotensin; blood pressure; hemodialysis; kidney transplantation.

MeSH terms

  • Angiotensin I / blood
  • Angiotensin II / blood
  • Antihypertensive Agents / pharmacology
  • Comorbidity
  • Humans
  • Kidney Transplantation*
  • Models, Biological
  • Renal Dialysis
  • Renin / blood
  • Renin-Angiotensin System* / drug effects

Substances

  • Antihypertensive Agents
  • Angiotensin II
  • Angiotensin I
  • Renin