"TrkA"cking why "no pain, no gain" is the rule for bone formation

Sci Transl Med. 2017 May 10;9(389):eaan3780. doi: 10.1126/scitranslmed.aan3780.


Peripheral sensory nerves expressing TrkA innervate long bones and stimulate bone formation through the Wnt/β-catenin pathway when placed under stress.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Osteogenesis / genetics
  • Osteogenesis / physiology*
  • Sensory Receptor Cells / metabolism*
  • Wnt Signaling Pathway / genetics
  • Wnt Signaling Pathway / physiology
  • beta Catenin / metabolism


  • beta Catenin