A Ferroelectric Ceramic/Polymer Composite-Based Capacitive Electrode Array for In Vivo Recordings

Changyong Chen; Miaomiao Xue; Yige Wen; Guang Yao; Yan Cui; Feiyi Liao; Zhuocheng Yan; Long Huang; Saeed Ahmed Khan; Min Gao; Taisong Pan; Hulin Zhang; Wei Jing; Daqing Guo; Sanfeng Zhang; Hailiang Yao; Xiong Zhou; Qiang Li; Yang Xia; Yuan Lin

doi:10.1002/adhm.201700305

A Ferroelectric Ceramic/Polymer Composite-Based Capacitive Electrode Array for In Vivo Recordings

Adv Healthc Mater. 2017 Aug;6(16). doi: 10.1002/adhm.201700305. Epub 2017 May 11.

Authors

Changyong Chen¹, Miaomiao Xue², Yige Wen¹, Guang Yao¹, Yan Cui², Feiyi Liao¹, Zhuocheng Yan¹, Long Huang¹, Saeed Ahmed Khan¹, Min Gao^{1

3}, Taisong Pan¹, Hulin Zhang¹, Wei Jing², Daqing Guo^{2

3}, Sanfeng Zhang⁴, Hailiang Yao⁴, Xiong Zhou⁴, Qiang Li⁴, Yang Xia^{2

3}, Yuan Lin^{1

3}

Affiliations

¹ State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China (UESTC), Chengdu, Sichuan, 610054, P. R. China.
² Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China (UESTC), Chengdu, Sichuan, 610054, P. R. China.
³ Center for Information in BioMedicine, University of Electronic Science and Technology of China (UESTC), Chengdu, Sichuan, 610054, P. R. China.
⁴ Integrated Systems Laboratory, University of Electronic Science and Technology of China (UESTC), Chengdu, Sichuan, 610054, P. R. China.

PMID: 28493386
DOI: 10.1002/adhm.201700305

Abstract

A new implantable capacitive electrode array for electrocorticography signal recording is developed with ferroelectric ceramic/polymer composite. This ultrathin and electrically safe capacitive electrode array is capable of attaching to the biological tissue conformably. The barium titanate/polyimide (BaTiO₃ /PI) nanocomposite with high dielectric constant is successfully synthesized and employed as the ultrathin dielectric layer of the capacitive BaTiO₃ /PI electrode array. The performance of the capacitive BaTiO₃ /PI electrode array is evaluated by electrical characterization and 3D finite-element modeling. In vivo, neural experiments on the visual cortex of rats show the reliability of the capacitive BaTiO₃ /PI electrode array. This work shows the potentials of capacitive BaTiO₃ /PI electrode array in the field of brain/computer interfaces.

Keywords: barium titanate/polyimide (BaTiO3/PI); brain/computer interfaces (BCI); capacitive sensing; electrocorticography (ECoG); electrode arrays.

MeSH terms

Animals
Barium Compounds / chemistry
Ceramics / chemistry
Electrodes, Implanted*
Electroencephalography / instrumentation*
Equipment Design
Finite Element Analysis
Male
Microelectrodes*
Nanocomposites / chemistry*
Polymers / chemistry
Rats
Rats, Wistar
Reproducibility of Results
Titanium / chemistry
Visual Cortex / physiology
Visual Cortex / surgery

Substances

Barium Compounds
Polymers
barium titanate(IV)
Titanium