RAS and ROS-A Story of Pseudomonas Survival

Stacey L Kolar; George Y Liu

doi:10.1016/j.chom.2017.04.009

RAS and ROS-A Story of Pseudomonas Survival

Cell Host Microbe. 2017 May 10;21(5):551-552. doi: 10.1016/j.chom.2017.04.009.

Authors

Stacey L Kolar¹, George Y Liu²

Affiliations

¹ Division of Pediatric Infectious Diseases and the Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
² Division of Pediatric Infectious Diseases and the Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: george.liu@cshs.org.

PMID: 28494232
DOI: 10.1016/j.chom.2017.04.009

Abstract

Some pathogens block generation of reactive oxygen species to evade neutrophil killing, but how that is accomplished is poorly understood. In this issue of Cell Host & Microbe, Vareechon et al. (2017) describe ADP-ribosylation of Ras as a strategy to inhibit assembly of neutrophil NADPH oxidase.

MeSH terms

ADP-Ribosylation
Genes, ras / physiology*
NADPH Oxidases / metabolism
Neutrophils / immunology
Neutrophils / metabolism
Neutrophils / microbiology
Pneumonia, Pneumococcal / immunology
Pneumonia, Pneumococcal / metabolism
Pseudomonas / genetics
Pseudomonas / immunology*
Pseudomonas / metabolism
Reactive Oxygen Species / immunology*
Reactive Oxygen Species / metabolism
Signal Transduction

Substances

Reactive Oxygen Species
NADPH Oxidases