Presence of inflammatory proteins S100A8 and S100A9 in a giant intracranial aneurysm after flow diverter treatment

Br J Neurosurg. 2019 Jun;33(3):258-260. doi: 10.1080/02688697.2017.1327019. Epub 2017 May 12.


We demonstrate the presence of S100A8 and S100A9 proteins in the wall and thrombosed lumen of an enlarged intracranial aneurysm after flow diverter treatment. These proteins have shown to play an important role in vascular inflammation and may serve as a biomarker and potential therapeutic target for intracranial aneurysms.

Keywords: Intracranial aneurysm; S100A8; S100A9; aneurysm enlargement; flow diverter.

Publication types

  • Case Reports

MeSH terms

  • Angiography, Digital Subtraction
  • Blood Vessel Prosthesis
  • Blood Vessel Prosthesis Implantation
  • Calgranulin A / analysis
  • Calgranulin A / metabolism*
  • Calgranulin B / analysis
  • Calgranulin B / metabolism*
  • Embolization, Therapeutic
  • Endovascular Procedures
  • Female
  • Humans
  • Immunohistochemistry
  • Intracranial Aneurysm / diagnostic imaging
  • Intracranial Aneurysm / metabolism*
  • Intracranial Aneurysm / surgery*
  • Middle Aged
  • Neurosurgical Procedures
  • Treatment Outcome
  • Vision Disorders / etiology


  • Calgranulin A
  • Calgranulin B
  • S100A8 protein, human
  • S100A9 protein, human