How to design a randomised controlled trial

doi:10.1038/sj.bdj.2017.411

. 2017 May 12;222(9):721-726.

doi: 10.1038/sj.bdj.2017.411.

How to design a randomised controlled trial

P Brocklehurst¹, Z Hoare²

Affiliations

¹ Director of NWORTH Clinical Trials Unit and Honorary Consultant in Dental Public Health.
² Principal Statistician, NWORTH Clinical Trials Unit.

PMID: 28496211
DOI: 10.1038/sj.bdj.2017.411

How to design a randomised controlled trial

P Brocklehurst et al. Br Dent J. 2017.

. 2017 May 12;222(9):721-726.

doi: 10.1038/sj.bdj.2017.411.

Authors

P Brocklehurst¹, Z Hoare²

Affiliations

¹ Director of NWORTH Clinical Trials Unit and Honorary Consultant in Dental Public Health.
² Principal Statistician, NWORTH Clinical Trials Unit.

PMID: 28496211
DOI: 10.1038/sj.bdj.2017.411

Abstract

This practical paper explains how to design an randomised controlled trial (RCT) for those who have little prior knowledge of the topic. It covers the basics of radomisation, statistical testing, sample size caluclations, bias and the role of Clinical Trial Units.

PubMed Disclaimer

Cited by

Effectiveness of multi-modal cognitive behavioural therapy in improving mental well-being among caregivers of children with disabilities in urban Uganda: A cluster-randomized controlled trial.
Namasaba M, Nabunje S, Baguwemu AA. Namasaba M, et al. J Glob Health. 2022 Dec 29;12:04102. doi: 10.7189/jogh.12.04102. J Glob Health. 2022. PMID: 36579518 Free PMC article. Clinical Trial.
Treatment protocols for claw horn lesions and their impact on lameness recovery, pain sensitivity, and lesion severity in moderately lame primiparous dairy cows.
Sadiq MB, Ramanoon SZ, Shaik Mossadeq WM, Mansor R, Syed-Hussain SS. Sadiq MB, et al. Front Vet Sci. 2022 Dec 8;9:1060520. doi: 10.3389/fvets.2022.1060520. eCollection 2022. Front Vet Sci. 2022. PMID: 36570514 Free PMC article.
Cost-effectiveness analysis of a chronic back pain multidisciplinary biopsychosocial rehabilitation (MBR) compared to standard care for privately insured in Germany.
Hochheim M, Ramm P, Wunderlich M, Amelung V. Hochheim M, et al. BMC Health Serv Res. 2021 Dec 24;21(1):1362. doi: 10.1186/s12913-021-07337-9. BMC Health Serv Res. 2021. PMID: 34952585 Free PMC article. Clinical Trial.
Effect of open versus closed endotracheal suctioning on intracranial pressure in severe brain-injured children: Study protocol for a randomized controlled trial.
Li Y, Li X, Wen Z, Zhang X, Liu Y, Wei L. Li Y, et al. Nurs Open. 2021 Sep;8(5):2886-2891. doi: 10.1002/nop2.656. Epub 2021 May 26. Nurs Open. 2021. PMID: 34037323 Free PMC article.

References

1. BMC Med Res Methodol. 2006 Nov 08;6:54 - PubMed
1. BMJ. 2005 Apr 2;330(7494):753 - PubMed
1. Ann Intern Med. 2013 Feb 5;158(3):200-7 - PubMed
1. Trials. 2013 Jan 17;14:19 - PubMed
1. PLoS One. 2016 Mar 15;11(3):e0150205 - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Other Literature Sources
- scite Smart Citations

[1] BMC Med Res Methodol. 2006 Nov 08;6:54 - PubMed

[2] BMC Med Res Methodol. 2006 Nov 08;6:54 - PubMed

[3] BMJ. 2005 Apr 2;330(7494):753 - PubMed

[4] BMJ. 2005 Apr 2;330(7494):753 - PubMed

[5] Ann Intern Med. 2013 Feb 5;158(3):200-7 - PubMed

[6] Ann Intern Med. 2013 Feb 5;158(3):200-7 - PubMed

[7] Trials. 2013 Jan 17;14:19 - PubMed

[8] Trials. 2013 Jan 17;14:19 - PubMed

[9] PLoS One. 2016 Mar 15;11(3):e0150205 - PubMed

[10] PLoS One. 2016 Mar 15;11(3):e0150205 - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

How to design a randomised controlled trial

Affiliations

How to design a randomised controlled trial

Authors

Affiliations

Abstract

Similar articles

Cited by

References

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources