Abstract
The effects of nor-binaltorphimine (nor-BNI) and beta-funaltrexamine (beta-FNA) were studied on the diuretic activities in rats of several kappa opioid agonists including ethylketazocine, tifluadom, bremazocine and U50,488H. Nor-BNI suppressed the diuretic activity of all kappa agonists, whereas beta-FNA failed to alter the diuresis. On the other hand, beta-FNA treatment completely blocked the morphine-induced antidiuresis, whereas nor-BNI had no effect. The present data add further evidence that nor-BNI is a highly selective antagonist of kappa opioid agonists.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
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Animals
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Diuresis / drug effects*
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Dose-Response Relationship, Drug
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Male
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Morphine / pharmacology
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Naltrexone / analogs & derivatives*
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Naltrexone / pharmacology
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Narcotic Antagonists / pharmacology*
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Pyrrolidines / pharmacology
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Rats
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Receptors, Opioid / drug effects*
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Receptors, Opioid, kappa
Substances
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Narcotic Antagonists
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Pyrrolidines
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Receptors, Opioid
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Receptors, Opioid, kappa
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norbinaltorphimine
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Naltrexone
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3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
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beta-funaltrexamine
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Morphine