Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Nov 20;6(2):88-92.
doi: 10.15171/jrip.2017.17. eCollection 2017.

Relationship Between Serum Irisin, Glycemic Indices, and Renal Function in Type 2 Diabetic Patients

Affiliations
Free PMC article

Relationship Between Serum Irisin, Glycemic Indices, and Renal Function in Type 2 Diabetic Patients

Leila Mahmoodnia et al. J Renal Inj Prev. .
Free PMC article

Abstract

Introduction: Irisin is a novel peptide that plays notable role in human and animal biology and physiology. It has been reported that irisin may improve insulin resistance and related disturbances. Objectives: The aim of this investigation was to assess the relationship between serum irisin, glycemic indices, and renal function in diabetic subjects. Patients and Methods: In this cross-sectional study, a total of 102 type 2 diabetes mellitus (T2DM) patients were recruited. Blood biochemical parameters, including fasting plasma sugar (FBS), glycosylated hemoglobin (HbA1C), serum uric acid (sUA), creatinine concentration and glomerular filtration rate (GFR) were measured. All statistical analysis was performed with SPSS 16.0. Results: There was a positive correlation between irisin and age (P=0.05, r=0.19) and a negative correlation between irisin and body mass index (BMI) (P=0.01, r=-0.25) was detected. There was a significant difference of serum irisin level between patients with normal and abnormal FBS too. Conclusion: In this study we found, irisin concentration was increased with age, decreased with BMI, and it was higher in subject with abnormal FBS. Thus further research is needed to provide inclusive understanding of irisin associated physiological effects and possible implications in clinical conditions.

Keywords: Body mass index; Irisin; Type 2 diabetic patients.

Similar articles

See all similar articles

Cited by 3 articles

References

    1. Guariguata L, Whiting D, Hambleton I, Beagley J, Linnenkamp U, Shaw J. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014;103:137–49. doi: 10.1016/j.diabres.2013.11.002. - DOI - PubMed
    1. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC. et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481:463–8. doi: 10.1038/nature10777. - DOI - PMC - PubMed
    1. Crujeiras AB, Pardo M, Arturo RR, Santiago NC, Zulet M, Martínez JA. et al. Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women. Am J Hum Biol. 2014;26:198–207. doi: 10.1002/ajhb.22493. - DOI - PubMed
    1. Du XL, Jiang WX, Lv ZT. Lower circulating irisin level in patients with diabetes mellitus: a systematic review and meta-analysis. Horm Metab Res. 2016;48:644–652. doi: 10.1055/s-0042-108730. - DOI - PubMed
    1. Huh JH, Ahn SV, Choi JH, Koh SB, Chung CH. High Serum irisin level as an independent predictor of diabetes mellitus: a longitudinal population-based study. Medicine. 2016;95:e3742. doi: 10.1097/MD.0000000000003742. - DOI - PMC - PubMed

LinkOut - more resources

Feedback