New Strategies in Rectal Cancer

Surg Clin North Am. 2017 Jun;97(3):587-604. doi: 10.1016/j.suc.2017.01.008.


In recent years, our understanding of rectal cancer has improved, including how locally advanced disease responds to chemotherapy and radiation. This has led to new innovations and advances in the treatment of rectal cancer, which includes organ-preserving strategies for responsive disease, and minimally invasive approaces for the performance of total mesorectal excision/protectomyh for persistently advanced disease. This article discusses new strategies for rectal cancer therapy, including Watch and Wait, local excision, minimally invasive proctectomy, and transanal total mesorectal excision particularly in the setting of preoperative multimodality treatment.

Keywords: Local excision; Organ-preserving strategies; Transanal TME; Watch and wait.

Publication types

  • Review

MeSH terms

  • Chemoradiotherapy, Adjuvant*
  • Digestive System Surgical Procedures / methods
  • Humans
  • Minimally Invasive Surgical Procedures
  • Positron Emission Tomography Computed Tomography
  • Radiography
  • Rectal Neoplasms / diagnostic imaging
  • Rectal Neoplasms / pathology
  • Rectal Neoplasms / surgery*
  • Rectal Neoplasms / therapy*