Chicken-activated-T-lymphocyte-antigen (CATLA) Recognized by Monoclonal Antibody INN-CH 16 Represents the IL-2 Receptor

Dev Comp Immunol. Fall 1988;12(4):823-31. doi: 10.1016/0145-305x(88)90056-0.

Abstract

Monoclonal antibody INN-CH 16 recognizes a surface determinant exclusively present on activated chicken T lymphocytes. The present experiments suggest that this chicken activated T lymphocyte antigen (CATLA) represents the chicken IL-2 receptor or an associated structure, as (i) the kinetics of CATLA expression during T cell activation are analogous to those described for the mammalian receptor for IL-2, (ii) the IL-2 dependent proliferation of mitogen prestimulated chicken lymphocytes is competitively inhibited by INN-CH 16, and (iii) pretreatment of T lymphoblasts with INN-CH 16 drastically reduces their capacity to absorb IL-2 activity from supernatants of mitogen activated chicken lymphocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal*
  • Antigens, Surface / analysis*
  • Chickens
  • Interleukin-2 / pharmacology
  • Lymphocyte Activation*
  • Receptors, Interleukin-2 / analysis*
  • Tumor Necrosis Factor Receptor Superfamily, Member 7

Substances

  • Antibodies, Monoclonal
  • Antigens, Surface
  • Interleukin-2
  • Receptors, Interleukin-2
  • Tumor Necrosis Factor Receptor Superfamily, Member 7