Celiac Disease and Nonceliac Gluten Sensitivity

Runa D Watkins; Shamila Zawahir

doi:10.1016/j.pcl.2017.01.013

Celiac Disease and Nonceliac Gluten Sensitivity

Pediatr Clin North Am. 2017 Jun;64(3):563-576. doi: 10.1016/j.pcl.2017.01.013.

Authors

Runa D Watkins¹, Shamila Zawahir²

Affiliations

¹ Pediatric Gastroenterology & Nutrition, University of Maryland, 22 South Greene Street, N5W68, Baltimore, MD 21201, USA. Electronic address: rwatkins@peds.umaryland.edu.
² Pediatric Gastroenterology & Nutrition, University of Maryland, 22 South Greene Street, N5W68, Baltimore, MD 21201, USA.

PMID: 28502438
DOI: 10.1016/j.pcl.2017.01.013

Abstract

Gluten-related disorders include celiac disease (CD), wheat allergy, and nonceliac gluten sensitivity. CD is an autoimmune enteropathy caused by damage to small intestinal mucosa when gluten is ingested in genetically susceptible individuals. Currently, the only available treatment of CD is gluten-free diet. Several potential treatments are being researched. Wheat allergy is a hypersensitivity reaction caused by IgE-mediated and/or non-IgE-mediated immune response, and can involve the gastrointestinal tract, skin, or respiratory tract. Nonceliac gluten sensitivity is one of a variety of immunologic, morphologic, or symptomatic manifestations precipitated by ingestion of gluten in individuals in whom CD and wheat allergy are excluded.

Keywords: Autoimmune; Celiac disease; Children; Gluten-free diet; Nonceliac gluten sensitivity; Tissue transglutaminase; Wheat allergy.

Publication types

Review

MeSH terms

Celiac Disease / diagnosis*
Celiac Disease / therapy
Diet, Gluten-Free / methods*
Female
Glutens
Humans
Male
Polyendocrinopathies, Autoimmune / diagnosis*
Polyendocrinopathies, Autoimmune / therapy
Wheat Hypersensitivity / diagnosis*
Wheat Hypersensitivity / therapy

Substances

Glutens

Supplementary concepts

Autoimmune enteropathy