Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 64 (3), 563-576

Celiac Disease and Nonceliac Gluten Sensitivity

Affiliations
Review

Celiac Disease and Nonceliac Gluten Sensitivity

Runa D Watkins et al. Pediatr Clin North Am.

Abstract

Gluten-related disorders include celiac disease (CD), wheat allergy, and nonceliac gluten sensitivity. CD is an autoimmune enteropathy caused by damage to small intestinal mucosa when gluten is ingested in genetically susceptible individuals. Currently, the only available treatment of CD is gluten-free diet. Several potential treatments are being researched. Wheat allergy is a hypersensitivity reaction caused by IgE-mediated and/or non-IgE-mediated immune response, and can involve the gastrointestinal tract, skin, or respiratory tract. Nonceliac gluten sensitivity is one of a variety of immunologic, morphologic, or symptomatic manifestations precipitated by ingestion of gluten in individuals in whom CD and wheat allergy are excluded.

Keywords: Autoimmune; Celiac disease; Children; Gluten-free diet; Nonceliac gluten sensitivity; Tissue transglutaminase; Wheat allergy.

Similar articles

See all similar articles

Cited by 3 PubMed Central articles

Supplementary concepts

Feedback