The effect of autologous activated platelet-rich plasma injection on female pattern hair loss: A randomized placebo-controlled study

J Cosmet Dermatol. 2018 Feb;17(1):47-53. doi: 10.1111/jocd.12357. Epub 2017 May 14.


Background: Hair is an essential part of a woman's appearance and attractiveness. This is reflected in the predominantly psychological morbidity that can be associated with female pattern hair loss. Platelet-rich plasma(PRP) has been used in numerous fields of medicine. Recently, PRP has received growing attention as a potential therapeutic tool for hair loss.

Objective: To evaluate the efficacy and safety of autologous platelet-rich plasma in the treatment of female pattern hair loss.

Materials and methods: Thirty female patients with female pattern hair loss were randomly assigned to receive autologous PRP injection into a selected area, and another area was injected with normal saline as a placebo. Sessions were performed weekly for a maximum total of four sessions. Patients were followed up 6 months after the end of last session. The outcome was assessed both subjectively and objectively.

Results: There was a statistical significant difference between PRP and placebo areas (P<.005) regarding both hair density and hair thickness as measured by a folliscope. The hair pull test became negative in PRP-injected areas in 25 patients (83%) with average number of three hairs. Global pictures showed a significant improvement in hair volume and quality together with a high overall patient satisfaction in PRP-injected sites, and these results were maintained during the 6-month follow- up.

Conclusion: Platelet-rich plasma injections can be regarded as an alternative for the treatment of female pattern hair loss with minimal morbidity and a low cost-to-benefit ratio.

Keywords: female pattern hair loss; hair pull test; platelet-rich plasma.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Alopecia / diagnosis
  • Alopecia / drug therapy*
  • Analysis of Variance
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Hair / drug effects
  • Hair / growth & development*
  • Humans
  • Injections, Intradermal
  • Middle Aged
  • Platelet-Rich Plasma*
  • Reference Values
  • Severity of Illness Index
  • Statistics, Nonparametric
  • Treatment Outcome
  • Young Adult