Human Chorionic Gonadotropin: The Pregnancy Hormone and More

Int J Mol Sci. 2017 May 14;18(5):1059. doi: 10.3390/ijms18051059.


To thoroughly review the uses of human chorionic gonadotropin (hCG) related to the process of reproduction and also assess new, non-traditional theories. Review of the international literature and research studies. hCG and its receptor, LH/CGR, are expressed in numerous sites of the reproductive tract, both in gonadal and extra-goanadal tissues, promoting oocyte maturation, fertilization, implantation and early embryo development. Moreover, hCG seems to have a potential role as an anti-rejection agent in solid organ transplantation. Future research needs to focus extensively on the functions of hCG and its receptor LH/CGR, in an effort to reveal known, as well as unknown clinical potentials.

Keywords: LH/CGR; endometrial synchrony; hCG; immunization; oocyte maturation; ovulation induction.

Publication types

  • Review

MeSH terms

  • Chorionic Gonadotropin / genetics*
  • Embryonic Development / genetics*
  • Female
  • Fertilization in Vitro
  • Gonadotropin-Releasing Hormone / genetics
  • Humans
  • Oocytes / growth & development*
  • Oocytes / metabolism
  • Pregnancy
  • Pregnancy Rate
  • Receptors, LH / genetics*


  • Chorionic Gonadotropin
  • Receptors, LH
  • Gonadotropin-Releasing Hormone