[HLA-B27 Positive Acute Anterior Uveitis - A Translational Perspective]

Klin Monbl Augenheilkd. 2017 May;234(5):652-656. doi: 10.1055/s-0043-105139. Epub 2017 May 15.
[Article in German]

Abstract

Background HLA-B27 positive acute anterior uveitis is the most common type of uveitis, and it is an autoimmune disease that can be triggered by infections. The precise mechanism of the interaction between involved microbes (mostly gram negative bacteria) and the host immune system is not clear. The disease probably results from an imbalance between pro- and anti-inflammatory components. Project description This article gives a compact overview about the current knowledge of the clinic and the etiopathogenesis of acute anterior uveitis as a basis for future research approaches. The goal of the current research is to classify the cellular and molecular pathogenetic factors in acute anterior uveitis. In this regard, a project on uveitis within the clinical research unit FOR 2240 "(Lymph)Angiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye", examines the hypothesis that dysregulation of regulatory cell populations and anti-inflammatory cytokines, such as interleukin-10 (IL-10), might contribute to the development of ocular autoimmunity following infections. The goal is to establish new markers for individual susceptibility in the risk group of the HLA-B27 positive population, because only about 1% of the HLA-B27 positive population will eventually develop acute anterior uveitis. Conclusions Translational research approaches to identify predisposed risk groups from the HLA-B27 population could improve patient care both on a prophylactic and a therapeutic level.

Publication types

  • Review

MeSH terms

  • Animals
  • Ciliary Body / immunology*
  • Cytokines / immunology*
  • Evidence-Based Medicine
  • HLA-B27 Antigen / immunology*
  • Humans
  • Immunologic Factors / immunology
  • Inflammation Mediators / immunology*
  • Iris / immunology*
  • Models, Immunological*
  • Translational Medical Research / trends
  • Uveitis, Anterior / drug therapy
  • Uveitis, Anterior / immunology*

Substances

  • Cytokines
  • HLA-B27 Antigen
  • Immunologic Factors
  • Inflammation Mediators