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Review
. 2017 Jun;46(2):253-272.
doi: 10.1016/j.gtc.2017.01.003.

Hepatocellular Adenomas: Morphology and Genomics

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Review

Hepatocellular Adenomas: Morphology and Genomics

Paulette Bioulac-Sage et al. Gastroenterol Clin North Am. .

Abstract

Hepatocellular adenomas (HCAs) are rare benign tumors. This single entity has been split into 3 subtypes corresponding to specific mutations: HNF1α-inactivated HCA; inflammatory HCA related to different mutations, all leading to activation of STAT3 pathway; and β-catenin-activated HCA related to CTNNB1 mutations. The risk of malignant transformation depends on the level of β-catenin activation, reported mainly for exon 3, including S45. It is possible using specific immunohistochemical markers to identify the 3 different HCA subtypes and the level of β-catenin activation. Fewer than 10% of HCAs remain unclassified.

Keywords: Genomics; Genoptye/phenotype; Hepatocellular adenoma classification; Hepatocellular adenomas; Malignant transformation.

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