MeCP2-deficient mice have reduced α4 and α6 nicotinic receptor mRNA and altered behavioral response to nicotinic agonists

Behav Brain Res. 2017 Jul 14:330:118-126. doi: 10.1016/j.bbr.2017.05.021. Epub 2017 May 12.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Disease Models, Animal
  • Female
  • Locomotion / drug effects
  • Male
  • Mesencephalon / drug effects
  • Mesencephalon / metabolism
  • Methyl-CpG-Binding Protein 2 / deficiency*
  • Methyl-CpG-Binding Protein 2 / genetics
  • Methyl-CpG-Binding Protein 2 / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Nicotine / pharmacology
  • Nicotinic Agonists / pharmacology*
  • Nicotinic Antagonists / pharmacology
  • Pyridines / pharmacology
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • Receptors, Nicotinic / genetics*
  • Receptors, Nicotinic / metabolism
  • Rett Syndrome / genetics
  • Rett Syndrome / metabolism
  • Rett Syndrome / physiopathology

Substances

  • Mecp2 protein, mouse
  • Methyl-CpG-Binding Protein 2
  • Nicotinic Agonists
  • Nicotinic Antagonists
  • Pyridines
  • RNA, Messenger
  • Receptors, Nicotinic
  • TC 2559
  • alpha(4)beta(4) nicotinic receptor
  • nicotinic receptor alpha6
  • Nicotine