Survival in children requiring chronic renal replacement therapy

Pediatr Nephrol. 2018 Apr;33(4):585-594. doi: 10.1007/s00467-017-3681-9. Epub 2017 May 15.


Survival in the pediatric end-stage renal disease (ESRD) population has improved substantially over recent decades. Nonetheless, mortality remains at least 30 times higher than that of healthy peers. Patient survival is multifactorial and dependent on various patient and treatment characteristics and degree of economic welfare of the country in which a patient is treated. In this educational review, we aim to delineate current evidence regarding mortality risk in the pediatric ESRD population and provide pediatric nephrologists with up-to-date information required to counsel affected families.

Keywords: Children; End-stage renal disease; Global disparity; Mortality risk; Outcomes; Registry data.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Cause of Death
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Kidney Failure, Chronic / mortality*
  • Kidney Failure, Chronic / therapy
  • Male
  • Renal Replacement Therapy / methods*
  • Risk Assessment / methods
  • Risk Factors
  • Survival Rate