Abstract
Two new compounds, philippin (1) and 3β,9α,14α-trihydroxy-(22E,24R)-ergost-22-en-7-one (2), were isolated from the fruiting bodies of Ganoderma philippii. Their structures were elucidated on the basis of the spectroscopic technologies, including 1D and 2D NMR as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) showed compound 1 exhibited weak inhibitory activity against AChE.
Keywords:
AChE inhibitory activity; Ganoderma philippii; Ganodermataceae; ergost; philippin.
MeSH terms
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Acetylcholinesterase / drug effects
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification*
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Cholinesterase Inhibitors / pharmacology
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Ergosterol / analogs & derivatives*
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Ergosterol / chemistry
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Ergosterol / isolation & purification
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Fruiting Bodies, Fungal / chemistry
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Ganoderma / chemistry*
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Hydroquinones / chemistry
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Hydroquinones / isolation & purification*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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3beta,9alpha,14alpha-trihydroxy-(22E,24R)-ergost-22-en-7-one
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Cholinesterase Inhibitors
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Hydroquinones
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philippin
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Acetylcholinesterase
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Ergosterol