Accelerating access and scale-up of optimized ART in low-income and middle-income countries: a call for a coordinated end-to-end approach

Curr Opin HIV AIDS. 2017 Jul;12(4):383-389. doi: 10.1097/COH.0000000000000383.


Purpose of review: To discuss how aligning the collective power of scientists, regulators, drug companies, donors, implementers and advocates to achieve a single goal - accelerating access to simpler, safer, more robust and more affordable HIV treatment - can rapidly advance antiretroviral optimization efforts and enable scale-up.

Recent findings: Harmonization of traditionally sequential processes can address the delays commonly experienced in introducing new products to low-income and middle-income countries, by facilitating an 'end-to-end' approach that mitigates risk and encourages early planning for all aspects of product introduction.

Summary: Planning with the 'end-in-mind' can facilitate healthy markets, benefit the application of new technologies, and accelerate the development of improved products in parallel (versus traditionally sequential efforts).

Publication types

  • Review

MeSH terms

  • Anti-HIV Agents / economics
  • Anti-HIV Agents / supply & distribution*
  • Developing Countries
  • Drug Costs*
  • HIV Infections / drug therapy*
  • HIV Infections / economics
  • Health Services Accessibility*
  • Humans


  • Anti-HIV Agents