Immunization During Pregnancy: Impact on the Infant

Paediatr Drugs. 2017 Aug;19(4):313-324. doi: 10.1007/s40272-017-0231-7.

Abstract

Maternal immunization has undergone a paradigm shift in recent years, as women and healthcare providers accept and recognize the benefits of this strategy not only for the pregnant woman but also for the developing fetus and young infant. This article reviews the evidence for active immunization during pregnancy, with an emphasis on perinatal and infant outcomes. Current recommendations for immunization during pregnancy are presented, with particular focus on the routinely recommended vaccines during pregnancy: influenza and Tdap (tetanus, diphtheria, and pertussis). We discuss future research directions, maternal vaccines in development, and considerations for optimizing and advancing this underutilized strategy.

Publication types

  • Review

MeSH terms

  • Diphtheria / immunology
  • Diphtheria / prevention & control
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / adverse effects
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology
  • Female
  • Humans
  • Immunity, Maternally-Acquired
  • Infant
  • Infant, Newborn
  • Influenza Vaccines / adverse effects
  • Influenza Vaccines / immunology
  • Influenza, Human / immunology
  • Influenza, Human / prevention & control
  • Pregnancy
  • Pregnancy Complications, Infectious / immunology
  • Pregnancy Complications, Infectious / prevention & control*
  • Tetanus / immunology
  • Tetanus / prevention & control
  • Vaccination*
  • Whooping Cough / immunology
  • Whooping Cough / prevention & control

Substances

  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Influenza Vaccines