Neural network imaging to characterize brain injury in cardiac procedures: the emerging utility of connectomics

Br J Anaesth. 2017 May 1;118(5):680-688. doi: 10.1093/bja/aex088.


Cognitive dysfunction is a poorly understood but potentially devastating complication of cardiac surgery. Clinically meaningful assessment of cognitive changes after surgery is problematic because of the absence of a means to obtain reproducible, objective, and quantitative measures of the neural disturbances that cause altered brain function. By using both structural and functional connectivity magnetic resonance imaging data to construct a map of the inter-regional connections within the brain, connectomics has the potential to increase the specificity and sensitivity of perioperative neurological assessment, permitting rational individualized assessment and improvement of surgical techniques.

Keywords: cardiac surgical procedures; connectome; coronary artery bypass; neuroimaging; off-pump; postoperative complications.

Publication types

  • Review

MeSH terms

  • Brain Injuries / diagnostic imaging*
  • Brain Injuries / psychology*
  • Cardiac Surgical Procedures / methods*
  • Cognition Disorders / diagnostic imaging*
  • Cognition Disorders / etiology
  • Cognition Disorders / psychology*
  • Connectome*
  • Humans
  • Nerve Net / diagnostic imaging*
  • Neural Pathways / anatomy & histology
  • Neural Pathways / diagnostic imaging
  • Postoperative Complications / diagnostic imaging*
  • Postoperative Complications / psychology*