Functional RNA structures throughout the Hepatitis C Virus genome

Curr Opin Virol. 2017 Jun;24:79-86. doi: 10.1016/j.coviro.2017.04.007. Epub 2017 May 13.

Abstract

The single-stranded Hepatitis C Virus (HCV) genome adopts a set of elaborate RNA structures that are involved in every stage of the viral lifecycle. Recent advances in chemical probing, sequencing, and structural biology have facilitated analysis of RNA folding on a genome-wide scale, revealing novel structures and networks of interactions. These studies have underscored the active role played by RNA in every function of HCV and they open the door to new types of RNA-targeted therapeutics.

Publication types

  • Review

MeSH terms

  • 3' Untranslated Regions
  • Animals
  • Genome, Viral*
  • Hepacivirus / genetics*
  • Hepacivirus / physiology
  • Hepatitis C / therapy
  • Hepatitis C / virology
  • Humans
  • Internal Ribosome Entry Sites
  • Mice
  • Nucleic Acid Conformation
  • Open Reading Frames
  • RNA, Viral / chemistry*
  • RNA, Viral / metabolism*
  • Viral Proteins / genetics
  • Viral Proteins / metabolism
  • Virus Replication

Substances

  • 3' Untranslated Regions
  • Internal Ribosome Entry Sites
  • RNA, Viral
  • Viral Proteins