Silexan in Anxiety Disorders: Clinical Data and Pharmacological Background

World J Biol Psychiatry. 2018 Sep;19(6):412-420. doi: 10.1080/15622975.2017.1331046. Epub 2017 Jun 19.

Abstract

Objectives: Silexan is a lavender oil preparation available in 80-mg capsules. Here we review clinical trials investigating its anxiolytic efficacy, safety and tolerability in humans, as well as preclinical investigations supporting this therapeutic use.

Methods: Besides three selected publications reporting preclinical investigations, seven clinical trials are included, of which five had a treatment duration of 6 or 10 weeks. Primary outcome measure was the HAM-A total score reduction, while single items were assessed with regard to effects on concomitant depressive symptoms and on quality of sleep.

Results: In patients with subthreshold (subsyndromal) anxiety or generalised anxiety disorder (GAD), an anxiolytic effect of Silexan was evident after 2 weeks. HAM-A total score reductions between baseline and end of treatment were significantly superior to placebo in patients with subthreshold anxiety and comparable with those achieved under lorazepam or paroxetine in patients with GAD. In addition, Silexan had beneficial effects on typical concomitant symptoms of anxiety disorders, such as impaired sleep, somatic complaints, co-morbid depression or decreased quality of life. Except for mild gastrointestinal symptoms, Silexan did not induce any adverse effects and did not cause drug interactions, sedation or withdrawal symptoms at daily doses of 80 or 160 mg.

Conclusions: Silexan is a safe and effective treatment in anxiety disorders.

Keywords: Silexan; anxiety disorder; clinical trial; lavender oil; pharmacology.

Publication types

  • Review

MeSH terms

  • Anti-Anxiety Agents / administration & dosage
  • Anti-Anxiety Agents / adverse effects
  • Anti-Anxiety Agents / pharmacology*
  • Anxiety Disorders / drug therapy*
  • Humans
  • Oils, Volatile / administration & dosage
  • Oils, Volatile / adverse effects
  • Oils, Volatile / pharmacology*
  • Phytotherapy / methods*
  • Plant Oils / administration & dosage
  • Plant Oils / adverse effects
  • Plant Oils / pharmacology*

Substances

  • Anti-Anxiety Agents
  • Oils, Volatile
  • Plant Oils
  • lavender oil