Treatment of severe hypocalcaemia due to osteoblastic metastases in a patient with post-thyroidectomy hypoparathyroidism with 153Sm-EDTMP

BMJ Case Rep. 2017 May 16:2017:bcr2017219354. doi: 10.1136/bcr-2017-219354.

Abstract

Symptomatic hypocalcaemia is an uncommon finding in patients with malignant tumours. We describe a patient with advanced metastatic breast cancer who developed severe hypocalcaemia caused by the combination of osteoblastic metastases and a permanent postoperative hypoparathyroidism. The patient failed to be treated with the conventional replacement therapy and was submitted effectively to radionucleotide therapy with 153Sm.

Keywords: Breast cancer; Calcium and bone.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravenous
  • Aged
  • Analgesics, Non-Narcotic / administration & dosage
  • Analgesics, Non-Narcotic / therapeutic use*
  • Bone Neoplasms / pathology
  • Bone Neoplasms / secondary*
  • Breast Neoplasms / complications
  • Breast Neoplasms / secondary*
  • Calcium / administration & dosage
  • Calcium / blood
  • Calcium / therapeutic use
  • Diagnosis, Differential
  • Female
  • Humans
  • Hypocalcemia / blood
  • Hypocalcemia / complications*
  • Hypocalcemia / drug therapy
  • Hypocalcemia / etiology
  • Hypoparathyroidism / blood
  • Hypoparathyroidism / complications*
  • Hypoparathyroidism / etiology
  • Organometallic Compounds / administration & dosage
  • Organometallic Compounds / therapeutic use*
  • Organophosphorus Compounds / administration & dosage
  • Organophosphorus Compounds / therapeutic use*
  • Osteoblasts / pathology*
  • Postoperative Complications
  • Radioisotopes / administration & dosage
  • Radioisotopes / therapeutic use*
  • Thyroidectomy / adverse effects*
  • Treatment Outcome

Substances

  • Analgesics, Non-Narcotic
  • Organometallic Compounds
  • Organophosphorus Compounds
  • Radioisotopes
  • samarium Sm-153 lexidronam
  • Calcium