hCG Triggering in ART: An Evolutionary Concept

Int J Mol Sci. 2017 May 17;18(5):1075. doi: 10.3390/ijms18051075.


Human chorionic gonadotropin (hCG) is no longer a single, omnipotent ovulation triggering option. Gonadotropin releasing hormone (GnRH) agonist, initially presented as a substitute for hCG, has led to a new era of administering GnRH agonist followed by hCG triggering. According to this new concept, GnRH agonist enables successful ovum maturation, while hCG supports the luteal phase and pregnancy until placental shift.

Keywords: LH receptor; chorionic gonadotropin; ovarian stimulation; ovulation induction.

Publication types

  • Review

MeSH terms

  • Biological Evolution
  • Chorionic Gonadotropin / pharmacology
  • Chorionic Gonadotropin / physiology*
  • Female
  • Fertilization in Vitro
  • Gene Expression Regulation / drug effects
  • Humans
  • Recombinant Proteins
  • Reproductive Physiological Phenomena*
  • Reproductive Techniques*
  • Signal Transduction / drug effects


  • Chorionic Gonadotropin
  • Recombinant Proteins