Emotional exhaustion-induced latent autoimmune diabetes in adults in a young lady: A CARE-compliant case report

Medicine (Baltimore). 2017 May;96(20):e6915. doi: 10.1097/MD.0000000000006915.


Rationale: Latent autoimmune diabetes in adults (LADA) refers to an autoimmune disorder characterized with detectable islets antibodies in the early diagnosis and increased autoimmune beta-cell failure progression. Notably, this kind of diabetes seems to be confused with other phenotypic diabetes.

Patient concerns: A young woman suffered an emotional exhaustion-induced LADA, showing asthenia, polydipsia, polyuria, and visible weight loss. The patient emotionally ended a 14-year romantic relationship, leading to the emotional flooding.

Diagnoses: The data from physical examination and laboratory tests exhibited as follows: glutamic acid decarboxylase antibody (GADA) = 63.83 U/mL, the fasting blood glucose (FBG) = 13.3 mmol/L, and glycated haemoglobin (HbA1c) = 10.9%. According to levels of GADA, the patient was diagnosed as LADA.

Interventions: The patient was clinically treated with insulin for 3-month. Then, running, diet-control, and emotional treatment were combined, such as the patient started a new relationship.

Outcomes: An emotional recovery initiated from a new romantic relationship and a baby, showing normal levels of GAD65 (27.007 IU/mL) and FBG (5.46) mmol/L.

Lessons: The emotional exhaustion might play a significant role in induction of LADA. It is important that individuals should maintain optimism, cheer, and a positive attitude.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Latent Autoimmune Diabetes in Adults / diagnosis
  • Latent Autoimmune Diabetes in Adults / etiology*
  • Latent Autoimmune Diabetes in Adults / psychology
  • Latent Autoimmune Diabetes in Adults / therapy
  • Stress, Psychological / complications*