The Effects of Gymnema sylvestre in High-Fat Diet-Induced Metabolic Disorders

Am J Chin Med. 2017;45(4):813-832. doi: 10.1142/S0192415X17500434. Epub 2017 May 18.


This study used an integrated approach to investigate the effects of Gymnema sylvestre (GS) extract as a functional dietary supplement with a high-fat diet. This approach examined insulin resistance, the dysfunction of adipose tissue, and liver steatosis. Male C57BL/6J mice were fed a normal chow or high-fat diet (HFD) for the acute and chronic study, in addition to GS in different doses (100, 250 and 500[Formula: see text]mg/kg body weight). Their body composition changes, serum lipid and glucose parameters, adipose and liver tissue histology, and gene expression were measured. It was found that GS significantly suppressed the increase of body weight, serum levels of lipid, insulin and leptin, and adipose tissue, and liver inflammation. GS also demonstrated hypoglycemic effects due to the amylase inhibition activity. Our results support the existence of a relationship between the HFD induced insulin resistance, adipose dysfunction and liver steatosis. In conclusion, GS works as a functional dietary supplement with preventative effects against metabolic disorder.

Keywords: Adiposity; Diabetes; High-fat Diet; Hyperglycemia; Obesity.

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Diet, High-Fat / adverse effects*
  • Dietary Supplements*
  • Disease Models, Animal
  • Gymnema sylvestre*
  • Hypoglycemic Agents
  • Insulin / metabolism
  • Insulin Resistance
  • Leptin / metabolism
  • Lipids / blood
  • Male
  • Metabolic Diseases / drug therapy*
  • Metabolic Diseases / etiology
  • Metabolic Diseases / metabolism
  • Metabolic Diseases / prevention & control*
  • Mice, Inbred C57BL
  • Plant Extracts / administration & dosage*
  • Plant Extracts / pharmacology*


  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Leptin
  • Lipids
  • Plant Extracts