Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death

Cell Calcium. 2018 Jan;69:62-72. doi: 10.1016/j.ceca.2017.05.003. Epub 2017 May 5.


The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures, as they intimately communicate, forming very dynamic platforms termed mitochondria-associated membranes (MAMs). In particular, the ER transmits proper Ca2+ signals to mitochondria, which decode them into specific inputs to regulate essential functions, including metabolism, energy production and apoptosis. Here, we will describe the different molecular players involved in the transfer of Ca2+ ions from the ER lumen to the mitochondrial matrix and how modifications in both ER-mitochondria contact sites and Ca2+ signaling can alter the cell death execution program.

Keywords: Apoptosis; Ca(2+) transfer; Calcium; Cell death; ER-mitochondria contact sites; Endoplasmic reticulum; Mitochondria; Mitochondria associated membranes (MAMs; Oncogenes; ROS; Tumor suppressors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Calcium / metabolism*
  • Calcium Signaling
  • Endoplasmic Reticulum / metabolism*
  • Homeostasis*
  • Humans
  • Mitochondria / metabolism*


  • Calcium