Severe neonatal alloimmune thrombocytopenia caused by maternal sensitization against a new low-frequency alloantigen (Dom b ) located on platelet glycoprotein IIIa

Transfusion. 2017 Jul;57(7):1847-1848. doi: 10.1111/trf.14160. Epub 2017 May 18.
No abstract available

MeSH terms

  • Amniocentesis
  • Antibody Specificity
  • Antigens, Human Platelet / genetics
  • Antigens, Human Platelet / immunology*
  • Female
  • Humans
  • Immunity, Maternally-Acquired / immunology*
  • Immunization
  • Immunoglobulins, Intravenous / therapeutic use
  • Infant, Newborn
  • Infant, Premature, Diseases / etiology*
  • Infant, Premature, Diseases / immunology
  • Infant, Premature, Diseases / therapy
  • Integrin alpha2
  • Integrin beta3 / genetics
  • Integrin beta3 / immunology*
  • Isoantigens / genetics
  • Isoantigens / immunology*
  • Male
  • Mutagenesis, Site-Directed
  • Mutation, Missense*
  • Platelet Count
  • Platelet Transfusion
  • Point Mutation*
  • Polymorphism, Single Nucleotide*
  • Pregnancy
  • Recombinant Proteins / immunology
  • Thrombocytopenia, Neonatal Alloimmune / etiology*
  • Thrombocytopenia, Neonatal Alloimmune / immunology
  • Thrombocytopenia, Neonatal Alloimmune / therapy

Substances

  • Antigens, Human Platelet
  • Dom(b) alloantigen, human
  • ITGA2B protein, human
  • ITGB3 protein, human
  • Immunoglobulins, Intravenous
  • Integrin alpha2
  • Integrin beta3
  • Isoantigens
  • Recombinant Proteins