Changes in lateral hypothalamic neuronal activity accompanying hyper- and hypoglycemias

Physiol Behav. 1988;44(3):347-54. doi: 10.1016/0031-9384(88)90036-4.


Blood glucose level and forebrain unit activity were simultaneously recorded in rats anesthetized with a ketamine IV infusion. Slight and transient fluctuations in glycemia, occurring either spontaneously or after IV injections of glucose or phlorizin, were observed. The spike frequency of more than 1/3 of the neurons tested in the lateral hypothalamic area was affected by these fluctuations. A majority of the responsive cells displayed either an activation during hypoglycemia or a depression during hyperglycemia. These neurons might mediate the effects of a drop in blood glucose on either meal initiation or neuroendocrine or autonomic events related to nutritional functions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / metabolism*
  • Brain Mapping
  • Hypothalamic Area, Lateral / physiology*
  • Male
  • Neurons / physiology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Cell Surface / physiology


  • Blood Glucose
  • Receptors, Cell Surface
  • glucose receptor