Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response

Int J Neuropsychopharmacol. 2017 Aug 1;20(8):619-623. doi: 10.1093/ijnp/pyx034.


Background: Major depressive disorder is a debilitating illness, which is most commonly treated with antidepressant drugs. As the majority of patients do not respond on their first trial, there is great interest in identifying biological factors that indicate the most appropriate treatment for each patient. Studies suggest that microRNA represent excellent biomarkers to predict antidepressant response.

Methods: We investigated the expression of miR-1202, miR-135a, and miR-16 in peripheral blood from 2 cohorts of depressed patients who received 8 weeks of antidepressant therapy. Expression was quantified at baseline and after treatment, and its relationship to treatment response and depressive symptoms was assessed.

Results: In both cohorts, responders displayed lower baseline miR-1202 levels compared with nonresponders, which increased following treatment.

Conclusions: Ultimately, our results support the involvement of microRNA in antidepressant response and suggest that quantification of their levels in peripheral samples represents a valid approach to informing treatment decisions.

Keywords: antidepressant response; major depressive disorder; microRNA.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antidepressive Agents / therapeutic use*
  • Biomarkers / blood
  • Citalopram / therapeutic use
  • Clinical Decision-Making
  • Depressive Disorder, Major / blood*
  • Depressive Disorder, Major / drug therapy*
  • Depressive Disorder, Treatment-Resistant / blood
  • Depressive Disorder, Treatment-Resistant / drug therapy
  • Desvenlafaxine Succinate / therapeutic use
  • Duloxetine Hydrochloride / therapeutic use
  • Humans
  • MicroRNAs / blood*
  • Psychiatric Status Rating Scales
  • ROC Curve
  • Treatment Outcome


  • Antidepressive Agents
  • Biomarkers
  • MIRN1202 microRNA, human
  • MIRN135 microRNA, human
  • MIRN16 microRNA, human
  • MicroRNAs
  • Citalopram
  • Duloxetine Hydrochloride
  • Desvenlafaxine Succinate