Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study)

BMC Musculoskelet Disord. 2017 May 18;18(1):201. doi: 10.1186/s12891-017-1565-6.


Background: To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis.

Methods: In a prospective cohort study, data from the second and third survey of the Nord-Trøndelag Health Study were linked to the Norwegian Arthroplasty Register in order to identify total hip or knee replacement as a result of primary osteoarthritis.

Results: Among 37 891 participants without previously known thyroid disease we recorded 978 total hip replacements (THRs) and 538 total knee replacements (TKRs) during a median follow-up time of 15.7 years. The analyses were adjusted for sex, age, BMI (body mass index), smoking, physical activity and diabetes. We did not find any association between TSH (thyroid stimulating hormone) and THR or TKR due to osteoarthritis. Neither were changes in TSH over time, or overt hypo- or hyperthyroidism, associated with incidence of THR or TKR.

Conclusion: No association was found between thyroid function and hip or knee joint replacement due to osteoarthritis.

Keywords: Hip joint replacement; Knee joint replacement; Osteoarthritis; Thyroid function; Thyroid stimulating hormone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthroplasty, Replacement, Hip / trends*
  • Arthroplasty, Replacement, Knee / trends*
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Norway / epidemiology
  • Osteoarthritis, Hip / diagnosis
  • Osteoarthritis, Hip / epidemiology*
  • Osteoarthritis, Hip / surgery
  • Osteoarthritis, Knee / diagnosis
  • Osteoarthritis, Knee / epidemiology*
  • Osteoarthritis, Knee / surgery
  • Prospective Studies
  • Risk Factors
  • Thyroid Diseases / diagnosis
  • Thyroid Diseases / epidemiology*