Biofunctional Microgel-Based Fertilizers for Controlled Foliar Delivery of Nutrients to Plants

Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7380-7386. doi: 10.1002/anie.201701620. Epub 2017 May 19.


Foliar application of micronutrients (e.g. Fe3+ ) onto plants over an extended time is challenging and often not possible due to insufficient rainfastness. Smart delivery systems which enable micronutrient release over several weeks would offer innovative and sustainable options to improve plant health and food production. Herein, we report a novel foliar fertilizer delivery system based on functional pH-responsive biohybrid microgels that have orthogonal functionality as carriers of micronutrients and employ peptides (termed anchor peptides) as foliar adhesion promoters. The anchor peptides bind to hydrophobic surfaces and the waxy "islands" of plant leaves. Our system requires no auxiliaries and is loadable, storable, and applicable from aqueous dispersion. We report the synthesis and functionalization of microgels, their loading with Fe3+ ions, and a proof of concept for the biofunctional microgel-based fertilizer system is demonstrated for iron-deficient cucumber plants.

Keywords: anchor peptides; fertilizers; microgels; nutrient uptake; polyelectrolytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chelating Agents / chemistry
  • Cross-Linking Reagents / chemistry
  • Cucumis sativus*
  • Ferric Compounds / administration & dosage
  • Fertilizers*
  • Gels / chemistry*
  • Hydrogen-Ion Concentration
  • Hydrophobic and Hydrophilic Interactions
  • Hydroxybenzoates / chemistry
  • Micronutrients*
  • Particle Size
  • Peptides / chemistry
  • Plant Growth Regulators*
  • Plant Leaves*
  • Polyamines / chemistry
  • Proof of Concept Study


  • Chelating Agents
  • Cross-Linking Reagents
  • Ferric Compounds
  • Fertilizers
  • Gels
  • Hydroxybenzoates
  • Micronutrients
  • Peptides
  • Plant Growth Regulators
  • Polyamines
  • polyallylamine
  • 2,3-dihydroxybenzoic acid