Ultrasmall Magnetic CuFeSe 2 Ternary Nanocrystals for Multimodal Imaging Guided Photothermal Therapy of Cancer

ACS Nano. 2017 Jun 27;11(6):5633-5645. doi: 10.1021/acsnano.7b01032. Epub 2017 May 25.


Nanoscale ternary chalcogenides have attracted intense research interest due to their wealth of tunable properties and diverse applications in energy and environmental and biomedical fields. In this article, ultrasmall magnetic CuFeSe2 ternary nanocrystals (<5.0 nm) were fabricated in the presence of thiol-functionalized poly(methacrylic acid) by an environmentally friendly aqueous method under ambient conditions. The small band gap and the existence of intermediate bands lead to a broad NIR absorbance in the range of 500-1100 nm and high photothermal conversion efficiency (82%) of CuFeSe2 nanocrystals. The resultant CuFeSe2 nanocrystals show superparamagnetism and effective attenuation for X-rays. In addition, they also exhibit excellent water solubility, colloidal stability, biocompatibility, and multifunctional groups. These properties enable them to be an ideal nanotheranostic agent for multimodal imaging [e.g., photoacoustic imaging (PAI), magnetic resonance imaging (MRI), computed tomography (CT) imaging] guided photothermal therapy of cancer.

Keywords: magnetic CuFeSe2; multimodal imaging; photothermal therapy; ternary semiconductors; ultrasmall nanocrystals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Copper / chemistry*
  • Hyperthermia, Induced / methods
  • Iron / chemistry*
  • Magnetic Resonance Imaging / methods
  • Male
  • Mice, Inbred BALB C
  • Multimodal Imaging / methods
  • Nanoparticles / chemistry
  • Nanoparticles / therapeutic use*
  • Neoplasms / diagnostic imaging*
  • Neoplasms / therapy*
  • Photoacoustic Techniques / methods
  • Phototherapy
  • Selenium Compounds / chemistry
  • Selenium Compounds / therapeutic use*
  • Theranostic Nanomedicine / methods*
  • Tomography, X-Ray Computed / methods


  • Selenium Compounds
  • Copper
  • Iron