"Expand and Click": A New Method for Labeling HIV-1 Envelope Glycoproteins

Cell Chem Biol. 2017 May 18;24(5):548-550. doi: 10.1016/j.chembiol.2017.05.006.

Abstract

In this issue of Cell Chemical Biology, Sakin et al. (2017) investigate the nanoscale behavior of the HIV-1 envelope (Env) glycoprotein complex by using genetic code expansion, bioorthogonal amino acids, synthetic dyes, and click chemistry. This minimally invasive approach allows the measurement of native Env cellular distribution and dynamics.

MeSH terms

  • Binding Sites
  • Click Chemistry
  • HIV-1*
  • Staining and Labeling / methods*
  • env Gene Products, Human Immunodeficiency Virus / chemistry*
  • env Gene Products, Human Immunodeficiency Virus / metabolism*

Substances

  • env Gene Products, Human Immunodeficiency Virus