Ketorolac, Oxymorphone, Tapentadol, and Tramadol: A Comprehensive Review

Anesthesiol Clin. 2017 Jun;35(2):e1-e20. doi: 10.1016/j.anclin.2017.01.001. Epub 2017 Apr 14.

Abstract

Pain remains a tremendous burden on patients and for the health care system, with uncontrolled pain being the leading cause of disability in this country. There are a variety of medications that can be used in the treatment of pain, including ketorolac, oxymorphone, tapentadol, and tramadol. Depending on the clinical situation, these drugs can be used as monotherapy or in conjunction with other types of medications in a multimodal approach. A strong appreciation of pharmacologic properties of these agents and potential side effects is warranted for clinicians.

Keywords: Analgesia; Ketorolac; Oxymorphone; Pain; Tapentadol; Tramadol.

Publication types

  • Review

MeSH terms

  • Analgesics, Opioid / adverse effects
  • Analgesics, Opioid / therapeutic use*
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Humans
  • Ketorolac / adverse effects
  • Ketorolac / therapeutic use*
  • Oxymorphone / adverse effects
  • Oxymorphone / therapeutic use*
  • Pain / drug therapy*
  • Pain Measurement
  • Phenols / adverse effects
  • Phenols / therapeutic use*
  • Tapentadol
  • Tramadol / adverse effects
  • Tramadol / therapeutic use*

Substances

  • Analgesics, Opioid
  • Anti-Inflammatory Agents, Non-Steroidal
  • Phenols
  • Tramadol
  • Oxymorphone
  • Tapentadol
  • Ketorolac