Usefulness of nutraceuticals in migraine prophylaxis

Neurol Sci. 2017 May;38(Suppl 1):117-120. doi: 10.1007/s10072-017-2901-1.


Several studies have supported the efficacy of complementary and alternative medicine approaches (physical, behavioral and nutraceutical therapies) in the treatment of headache disorders. Nutraceutical treatment consists of taking vitamins, supplements (magnesium, riboflavin, coenzyme Q10, and alpha lipoic acid) and herbal preparations (feverfew and butterbur), and its usage is frequently determined by dissatisfaction with conventional medical therapies. There is a growing body of research on nutraceutical use for migraine prophylaxis. This brief overview provides information about the potential efficacy and side effects of various nutraceutical products summarizing randomized controlled trials of some of the most commonly used non-pharmacological treatments for the prophylaxis and treatment of migraine, including magnesium, coenzyme Q10, riboflavin (vitamin B2), petasites, and feverfew.

Keywords: Headache; Migraine; Nutraceuticals; Vitamin.

Publication types

  • Review

MeSH terms

  • Dietary Supplements*
  • Humans
  • Magnesium / administration & dosage
  • Melatonin / administration & dosage
  • Migraine Disorders / diagnosis*
  • Migraine Disorders / diet therapy*
  • Migraine Disorders / drug therapy
  • Pre-Exposure Prophylaxis / methods*
  • Riboflavin / administration & dosage
  • Tanacetum parthenium
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives


  • Ubiquinone
  • coenzyme Q10
  • Magnesium
  • Melatonin
  • Riboflavin