An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants

Skin Pharmacol Physiol. 2017;30(3):146-158. doi: 10.1159/000464470. Epub 2017 May 20.


Background: Skin aging is a multifactorial phenomenon which causes alterations in skin physiological functions and, most visibly, phenotypic changes. In particular, during the aging process, hyaluronic acid, collagen, and elastin fibers undergo structural and functional changes.

Aims: This study aimed to give an insight into the photo-protective benefits and efficacy of an oral liquid nutricosmeceutical containing collagen bioactive peptides and antioxidants to counteract the signs of aging.

Methods: A double-blind, randomized, placebo-controlled clinical trial was conducted by an independent esthetic clinic on 120 healthy volunteer subjects for 90 days. Subjects were divided into 2 groups: 60 subjects consumed 1 bottle (50 mL) of the nutricosmeceutical daily and the other 60 consumed 1 bottle (50 mL) of the placebo. Outcome measures were related to skin elasticity (expressed as Young's elasticity modulus) and skin architecture (histological analysis). In addition, the subjects recruited in this study underwent observational assessments through self-assessment questionnaires.

Results and conclusions: Overall, we demonstrated a significant increase in skin elasticity (+7.5%), p ≤ 0.001 and an improvement in skin texture after daily oral consumption of the nutricosmeceutical. We also obtained a positive patient feedback through the self-assessment questionnaires. Taken together these results show that this nutricosmeceutical supplement may have photo-protective effects and help improve skin health.

Keywords: Antioxidants; Collagen peptides; GOLD COLLAGEN®; Nutricosmeceutical; Skin aging.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acetylglucosamine / pharmacology
  • Adult
  • Antioxidants / pharmacology*
  • Collagen / pharmacology*
  • Copper / pharmacology
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Humans
  • Hyaluronic Acid / pharmacology
  • Linoleic Acids / pharmacology
  • Male
  • Middle Aged
  • Oenothera biennis
  • Peptides / pharmacology*
  • Plant Oils / pharmacology
  • Skin / anatomy & histology
  • Skin / drug effects
  • Skin Aging / drug effects*
  • Skin Physiological Phenomena / drug effects*
  • Vitamins / pharmacology
  • Zinc / pharmacology
  • gamma-Linolenic Acid / pharmacology


  • Antioxidants
  • Linoleic Acids
  • Peptides
  • Plant Oils
  • Vitamins
  • evening primrose oil
  • Copper
  • gamma-Linolenic Acid
  • Hyaluronic Acid
  • Collagen
  • borage oil
  • Zinc
  • Acetylglucosamine