Brownian ratchet mechanisms of ParA-mediated partitioning

doi:10.1016/j.plasmid.2017.05.002

Review

. 2017 Jul:92:12-16.

doi: 10.1016/j.plasmid.2017.05.002. Epub 2017 May 18.

Brownian ratchet mechanisms of ParA-mediated partitioning

Longhua Hu¹, Anthony G Vecchiarelli², Kiyoshi Mizuuchi³, Keir C Neuman¹, Jian Liu⁴

Affiliations

¹ Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, United States.
² Department of Molecular, Cellular, and Developmental Biology (MCDB), University of Michigan, Ann Arbor, MI, United States.
³ Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States.
⁴ Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, United States. Electronic address: jian.liu@nih.gov.

PMID: 28529035
PMCID: PMC5568458
DOI: 10.1016/j.plasmid.2017.05.002

Review

Brownian ratchet mechanisms of ParA-mediated partitioning

Longhua Hu et al. Plasmid. 2017 Jul.

. 2017 Jul:92:12-16.

doi: 10.1016/j.plasmid.2017.05.002. Epub 2017 May 18.

Authors

Longhua Hu¹, Anthony G Vecchiarelli², Kiyoshi Mizuuchi³, Keir C Neuman¹, Jian Liu⁴

Affiliations

¹ Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, United States.
² Department of Molecular, Cellular, and Developmental Biology (MCDB), University of Michigan, Ann Arbor, MI, United States.
³ Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States.
⁴ Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, United States. Electronic address: jian.liu@nih.gov.

PMID: 28529035
PMCID: PMC5568458
DOI: 10.1016/j.plasmid.2017.05.002

No abstract available

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Figures

**Figure 1**
Schematic comparisons between different Brownian ratchet models for the ParA-mediated partition mechanism. (A). Mechanochemical Brownian ratchet model. (B) DNA-relay model. (C) Hitch-hiking model. For (A) and (B), the thickness of the DNA tether qualitatively scales with the stiffness of the spring. For (C), ParA molecules assemble in small patches in high DNA density regions within the nucleoid, and the partition complex is suggested to move to these high-density regions through a biased Brownian motion.

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References

1. Vecchiarelli AG, Mizuuchi K, Funnell BE. Surfing biological surfaces: exploiting the nucleoid for partition and transport in bacteria. Molecular Microbiology. 2012;86:513–523. - PMC - PubMed
1. Vecchiarelli AG, Hwang LC, Mizuuchi K. Cell-free study of F plasmid partition provides evidence for cargo transport by a diffusion-ratchet mechanism. Proceedings of the National Academy of Sciences. 2013;110:E1390–E1397. - PMC - PubMed
1. Vecchiarelli AG, Neuman KC, Mizuuchi K. A propagating ATPase gradient drives transport of surface-confined cellular cargo. Proceedings of the National Academy of Sciences. 2014;111:4880–4885. - PMC - PubMed
1. Hwang LC, Vecchiarelli AG, Han YÄ, Mizuuchi M, Harada Y, Funnell BE, Mizuuchi K. ParA-mediated plasmid partition driven by protein pattern self-organization. The EMBO Journal. 2013;32:1238–1249. - PMC - PubMed
1. Le Gall A, Cattoni DI, Guilhas B, Mathieu-Demaziere C, Oudjedi L, Fiche J-B, Rech J, Abrahamsson S, Murray H, Bouet J-Y, Nollmann M. Bacterial partition complexes segregate within the volume of the nucleoid. Nat Commun. 2016;7:12107. - PMC - PubMed

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[1] Vecchiarelli AG, Mizuuchi K, Funnell BE. Surfing biological surfaces: exploiting the nucleoid for partition and transport in bacteria. Molecular Microbiology. 2012;86:513–523. - PMC - PubMed

[2] Vecchiarelli AG, Mizuuchi K, Funnell BE. Surfing biological surfaces: exploiting the nucleoid for partition and transport in bacteria. Molecular Microbiology. 2012;86:513–523. - PMC - PubMed

[3] Vecchiarelli AG, Hwang LC, Mizuuchi K. Cell-free study of F plasmid partition provides evidence for cargo transport by a diffusion-ratchet mechanism. Proceedings of the National Academy of Sciences. 2013;110:E1390–E1397. - PMC - PubMed

[4] Vecchiarelli AG, Hwang LC, Mizuuchi K. Cell-free study of F plasmid partition provides evidence for cargo transport by a diffusion-ratchet mechanism. Proceedings of the National Academy of Sciences. 2013;110:E1390–E1397. - PMC - PubMed

[5] Vecchiarelli AG, Neuman KC, Mizuuchi K. A propagating ATPase gradient drives transport of surface-confined cellular cargo. Proceedings of the National Academy of Sciences. 2014;111:4880–4885. - PMC - PubMed

[6] Vecchiarelli AG, Neuman KC, Mizuuchi K. A propagating ATPase gradient drives transport of surface-confined cellular cargo. Proceedings of the National Academy of Sciences. 2014;111:4880–4885. - PMC - PubMed

[7] Hwang LC, Vecchiarelli AG, Han YÄ, Mizuuchi M, Harada Y, Funnell BE, Mizuuchi K. ParA-mediated plasmid partition driven by protein pattern self-organization. The EMBO Journal. 2013;32:1238–1249. - PMC - PubMed

[8] Hwang LC, Vecchiarelli AG, Han YÄ, Mizuuchi M, Harada Y, Funnell BE, Mizuuchi K. ParA-mediated plasmid partition driven by protein pattern self-organization. The EMBO Journal. 2013;32:1238–1249. - PMC - PubMed

[9] Le Gall A, Cattoni DI, Guilhas B, Mathieu-Demaziere C, Oudjedi L, Fiche J-B, Rech J, Abrahamsson S, Murray H, Bouet J-Y, Nollmann M. Bacterial partition complexes segregate within the volume of the nucleoid. Nat Commun. 2016;7:12107. - PMC - PubMed

[10] Le Gall A, Cattoni DI, Guilhas B, Mathieu-Demaziere C, Oudjedi L, Fiche J-B, Rech J, Abrahamsson S, Murray H, Bouet J-Y, Nollmann M. Bacterial partition complexes segregate within the volume of the nucleoid. Nat Commun. 2016;7:12107. - PMC - PubMed

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Brownian ratchet mechanisms of ParA-mediated partitioning

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Brownian ratchet mechanisms of ParA-mediated partitioning

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