The NMDA Receptor: Central Role in Pain Inhibition in Rat Periaqueductal Gray

Eur J Pharmacol. 1988 Sep 23;154(3):271-6. doi: 10.1016/0014-2999(88)90201-4.

Abstract

An injection of the excitatory amino acid analogue, N-methyl-D-aspartate (NMDA), in the rat periaqueductal gray resulted in potent analgesia. A prior injection of the NMDA antagonist, (-)-2-amino-7-phosphonoheptanoate (D-AP7), antagonized this action, indicating a receptor-mediated action. NMDA given with morphine potentiated the morphine analgesia while D-AP7 blocked morphine analgesia. These results delineate for the first time a functional role for the NMDA receptor in the control of pain in the mammalian central nervous system.

MeSH terms

  • 2-Amino-5-phosphonovalerate* / analogs & derivatives*
  • Amino Acids / pharmacology
  • Analgesia
  • Animals
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / pharmacology
  • Kainic Acid / pharmacology
  • Male
  • Morphine / pharmacology
  • N-Methylaspartate
  • Oxadiazoles / pharmacology
  • Pain / physiopathology*
  • Periaqueductal Gray / drug effects
  • Periaqueductal Gray / physiopathology*
  • Quisqualic Acid
  • Rats
  • Rats, Inbred Strains
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter / physiology*

Substances

  • Amino Acids
  • Oxadiazoles
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter
  • Aspartic Acid
  • N-Methylaspartate
  • 2-Amino-5-phosphonovalerate
  • Morphine
  • Quisqualic Acid
  • 2-amino-7-phosphonoheptanoic acid
  • Kainic Acid